#37 Detoxification Part-2 Fluoroquinolone Toxicity

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1.5 CE Total | 1.5 Pharm

Fluoroquinolones (FQs) are synthetic antibiotics that act by inhibiting bacterial DNA gyrase (topoisomerase II). DNA gyrase is directly involved in DNA replication and cell division. Theoretically, FQs should not exert a negative effect on human cell lines because the affected bacterial enzymes have little homology with mammalian DNA gyrase. However, it is possible that FQs have a direct cytotoxic effect on enzymes found in mammalian musculoskeletal tissue. This CME discusses the pathology, presentations, and therapies for this drug-induced pathology.

 

SKU: NAEMCDAMonthlyWebinar#37 Category:

Description

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Abstract

Fluoroquinolones (FQs) are synthetic antibiotics that act by inhibiting bacterial DNA gyrase (topoisomerase II). DNA gyrase is directly involved in DNA replication and cell division. Theoretically, FQs should not exert a negative effect on human cell lines because the affected bacterial enzymes have little homology with mammalian DNA gyrase. However, it is possible that FQs have a direct cytotoxic effect on enzymes found in mammalian musculoskeletal tissue. This CME discusses the pathology, presentations, and therapies for this drug-induced pathology.

Learning Objectives

  • Describe pathogenesis of FQ toxicity
  • Describe CNS effects
  • Describe assessment
  • Describe therapeutics

 

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