#103 Vitamin B6: Complex Biochemistry, Testing, Toxicity, and Appropriate Uses

Vitamin B6 has multiple mechanisms of action in humans. Additionally, its biochemistry is complex with multiple vitamers, all having potential effects in the body. Added to this complexity is the known effect of low B6 causing neuropathy, but also a bimodal “B6 toxicity state” where low or high levels of supplementation may trigger neuropathy as well. While there are many publications regarding the biochemistry, pharmacology, and toxicology of B6 a clear understanding of its toxicity is elusive in the data. This CME is designed to lay out the known science and give clinical guidelines for the safe use of vitamin B6, as well as strategies for dealing with potential toxicity.