Reactions that seem paradoxical to P5P can be from a plethora of genesis.
Most common are:
- Increase CBS and thus increase sulfite load (and if SUOX has been slow this can act like migraine, mania or insomnia) — this also can alter glutathione metabolism creating more “agitation” symptoms. —
- Increase TRYP & 5HTP conversion to Serotonin and increase the Melatonin substrate pool leading to either somnolence or agitation —
- Increase activity of AST and AALT suddenly relating to “active” liver symptoms —
- Also can suddenly cause shift in glutamate/histamine and other neurotransmitter metabolism.
* Most is transient but still may last 2-3 weeks
** If magnesium is not being supplemented enough (it is the main ionic co-factor for B6) then the reactions can be partially from that
*** If Mag is being supplemented then often the fault is in deficient Taurine (which allows magnesium and other minerals to equilibrate at cell membrane sites.
